User:HAL333/sandbox/viralvector

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Revision as of 00:34, 5 May 2024
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This ability to introduce new genetic material has been exploited by genetic engineers to create viral vectors, which can transfer the desired [[transgene]] into a target cell.{{sfn|Labbé|Vessillier|Rafiq|2021|p=1}} Viral vectors consists of three components:{{sfn|Bulcha|Wang|Ma|Tai|2021|p=1-2}}This ability to introduce new genetic material has been exploited by genetic engineers to create viral vectors, which can transfer the desired [[transgene]] into a target cell.{{sfn|Labbé|Vessillier|Rafiq|2021|p=1}} Viral vectors consists of three components:{{sfn|Bulcha|Wang|Ma|Tai|2021|p=1-2}}
#A protein capsid and/or envelope that encapsidates the genetic payload. This determines the target tissue or antigen recognition.#A [[Capsid|protein capsid]] and/or [[Viral envelope|envelope]] that encapsidates the genetic payload. This determines which cells the vector infects, known as its [[Tissue tropism|tropism]].
#The genetic payload: the transgene that results in the desired effect when expressed.#The genetic payload: the transgene that results in the desired effect when expressed.
#The "regulatory cassette" that allows for the expression of the trangene either as a chromosomal integrant or an episome. It comprises enhancer, promoter, and auxiliary elements.#The "regulatory cassette" that allows for the expression of the trangene either as a chromosomal integrant or an episome. It comprises enhancer, promoter, and auxiliary elements.

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