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{{Infobox scientist
| name = Shu-ou Shan
| birth_place = [[Shanghai]]
| workplaces = [[California Institute of Technology]]
| alma_mater = [[Stanford University]] <br> [[University of Maryland, College Park]]
| thesis_title = Energetic analysis of hydrogen bonds in model systems : implications for enzymatic catalysis
| thesis_url = https://searchworks.stanford.edu/view/5556630
| thesis_year = 1999
| doctoral_advisor = [[Daniel Herschlag]]
| academic_advisors = [[Peter Walter]]
| website = [http://shangroup.caltech.edu/Welcome.html Shan Lab]
}}
'''Shu-ou Shan''' is an American biologist and Professor at the [[California Institute of Technology]]. Her research combines mechanistic enzymology with biophysical characterisation techniques (e.g. [[Cryo em|cryo EM]] and fluorescence spectroscopy) to understand biogenesis pathways. She was awarded the 2024 [[National Academy of Sciences]] Award in Molecular Biology.
== Early life and education ==
Shan was born and raised in [[Shanghai]]. She moved to the [[United States]] after high school, and studied chemistry at the [[University of Maryland, College Park]]. She was a doctoral researcher at [[Stanford University]], where she worked alongside [[Daniel Herschlag]] on RNA catalysis.<ref name=":0">{{Cite journal |date=2016-10-20 |title=TrendsTalk |url=http://dx.doi.org/10.1016/j.tibs.2016.09.003 |journal=Trends in Biochemical Sciences |volume=41 |issue=12 |pages=983–984 |doi=10.1016/j.tibs.2016.09.003 |issn=0968-0004}}</ref> Here she was first introduced to mechanistic enzymology. She moved to [[University of California, San Francisco]] as a postdoctoral researcher, where she worked with [[Peter Walter]] on cell biology.<ref name=":0" />
== Research and career ==
In 2005 Shan joined the faculty aat [[California Institute of Technology]]. Her science is driven by questions about how cells control biological processes and the molecular principles that underpin biological recognition and mechanisms that define protein delivery.<ref name=":0" />
Shan looks to understand the molecular mechanisms of co-translational protein machineries; including folding, assembly, targeting and biogenesis.<ref>{{Cite web |title=Shan Lab - Research |url=http://shangroup.caltech.edu/Research.html |access-date=2024-05-08 |website=shangroup.caltech.edu}}</ref> Co-translational describes processes that occur at the same time as translation during protein synthesis.<ref name=":1">{{Cite web |title=Shu-ou Shan - Division of Chemistry and Chemical Engineering |url=https://cce.caltech.edu/people/shu-ou-shan |access-date=2024-05-08 |website=cce.caltech.edu}}</ref> Using an array of biophysical characterisation techniques Shan looks to build a model that can predict what happens to nascent proteins as they emerge from the ribosome and their environment impacts these processes.<ref name=":1" /><ref>{{Cite web |title=CalTech professor Shu-ou Shan speaks on nascent proteins |url=https://www.jhunewsletter.com/artic...fessor-shu-ou-shan-speaks-on-nascent-proteins |access-date=2024-05-08 |website=The Johns Hopkins News-Letter |language=en-US}}</ref>
She studies [[Chaperone (protein)|molecular chaperones]] (proteins that assist in the folding or unfolding process) and how they protect proteins from mis-folding, sometimes even repairing mis-folding or aggregation.<ref name=":1" />
== Awards and honours ==
* 2007 [[David and Lucile Packard Foundation]] Fellow<ref>{{Cite web |title=Shan, Shu-ou • The David and Lucile Packard Foundation |url=https://www.packard.org/fellow/shan-shu-ou/ |access-date=2024-05-08 |website=The David and Lucile Packard Foundation |language=en-US}}</ref>
* 2007 [[Arnold and Mabel Beckman]] Fellow<ref>{{Cite web |title=Shu-Ou Shan |url=https://www.beckman-foundation.org/people/shu-ou-shan/ |access-date=2024-05-08 |website=Arnold and Mabel Beckman Foundation |language=en-US}}</ref>
* 2011 [[Protein Society]] Irving Sigal Young Investigator Award<ref>{{Cite web |title=Protein Science Young Investigator Award |url=https://onlinelibrary.wiley.com/page/journal/1469896x/homepage/protein_science_awards.htm}}</ref><ref>{{Cite web |title=Protein Society Awards |url=https://www.proteinsociety.org/protein-society-awards |access-date=2024-05-08 |website=www.proteinsociety.org}}</ref>
* 2013 [[American Chemical Society]] Nobel Laureate Signature Award for Graduate Education in Chemistry<ref>{{Cite web |date=2012-03-16 |title=American Chemical Society Honors Shu-ou Shan |url=https://www.caltech.edu/about/news/american-chemical-society-honors-shu-ou-shan-4239 |access-date=2024-05-08 |website=California Institute of Technology |language=en}}</ref>
* 2013 [[American Society for Biochemistry and Molecular Biology]] Young Investigator Award<ref>{{Cite web |title=Shan honored for work uncovering mechanisms of signal recognition particle |url=https://www.asbmb.org/asbmb-today/people/032513/shan-wins-asbmb-young-investigator-award |access-date=2024-05-08 |website=www.asbmb.org |language=en}}</ref>
* 2020 [[Caltech]] Altair Professor of Chemistry<ref>{{Cite web |date=2020-10-09 |title=Caltech Faculty Receive Named Professorships |url=https://www.caltech.edu/about/news/caltech-faculty-receive-named-professorships-2020 |access-date=2024-05-08 |website=California Institute of Technology |language=en}}</ref>
* 2024 [[National Academy of Sciences]] Award in Molecular Biology<ref>{{Cite web |date=2024-02-08 |title=Caltech’s Shu-ou Shan Recognized for Her Research on Molecular Machines in Protein Folding |url=https://www.wiareport.com/2024/02/national-academy-of-sciences-honors-shu-ou-shan/ |access-date=2024-05-08 |website=Women In Academia Report}}</ref><ref>{{Cite web |date=2024-01-26 |title=Shu-ou Shan Wins National Academy of Sciences Award |url=https://www.caltech.edu/about/news/shan-wins-NAS-award |access-date=2024-05-08 |website=California Institute of Technology |language=en}}</ref>
== Select publications ==
* {{Cite Q|Q38081948}}
* {{Cite Q|Q70998826}}
* {{Cite Q|Q42956366}}
== References ==
Okumaya devam et...
{{Infobox scientist
| name = Shu-ou Shan
| birth_place = [[Shanghai]]
| workplaces = [[California Institute of Technology]]
| alma_mater = [[Stanford University]] <br> [[University of Maryland, College Park]]
| thesis_title = Energetic analysis of hydrogen bonds in model systems : implications for enzymatic catalysis
| thesis_url = https://searchworks.stanford.edu/view/5556630
| thesis_year = 1999
| doctoral_advisor = [[Daniel Herschlag]]
| academic_advisors = [[Peter Walter]]
| website = [http://shangroup.caltech.edu/Welcome.html Shan Lab]
}}
'''Shu-ou Shan''' is an American biologist and Professor at the [[California Institute of Technology]]. Her research combines mechanistic enzymology with biophysical characterisation techniques (e.g. [[Cryo em|cryo EM]] and fluorescence spectroscopy) to understand biogenesis pathways. She was awarded the 2024 [[National Academy of Sciences]] Award in Molecular Biology.
== Early life and education ==
Shan was born and raised in [[Shanghai]]. She moved to the [[United States]] after high school, and studied chemistry at the [[University of Maryland, College Park]]. She was a doctoral researcher at [[Stanford University]], where she worked alongside [[Daniel Herschlag]] on RNA catalysis.<ref name=":0">{{Cite journal |date=2016-10-20 |title=TrendsTalk |url=http://dx.doi.org/10.1016/j.tibs.2016.09.003 |journal=Trends in Biochemical Sciences |volume=41 |issue=12 |pages=983–984 |doi=10.1016/j.tibs.2016.09.003 |issn=0968-0004}}</ref> Here she was first introduced to mechanistic enzymology. She moved to [[University of California, San Francisco]] as a postdoctoral researcher, where she worked with [[Peter Walter]] on cell biology.<ref name=":0" />
== Research and career ==
In 2005 Shan joined the faculty aat [[California Institute of Technology]]. Her science is driven by questions about how cells control biological processes and the molecular principles that underpin biological recognition and mechanisms that define protein delivery.<ref name=":0" />
Shan looks to understand the molecular mechanisms of co-translational protein machineries; including folding, assembly, targeting and biogenesis.<ref>{{Cite web |title=Shan Lab - Research |url=http://shangroup.caltech.edu/Research.html |access-date=2024-05-08 |website=shangroup.caltech.edu}}</ref> Co-translational describes processes that occur at the same time as translation during protein synthesis.<ref name=":1">{{Cite web |title=Shu-ou Shan - Division of Chemistry and Chemical Engineering |url=https://cce.caltech.edu/people/shu-ou-shan |access-date=2024-05-08 |website=cce.caltech.edu}}</ref> Using an array of biophysical characterisation techniques Shan looks to build a model that can predict what happens to nascent proteins as they emerge from the ribosome and their environment impacts these processes.<ref name=":1" /><ref>{{Cite web |title=CalTech professor Shu-ou Shan speaks on nascent proteins |url=https://www.jhunewsletter.com/artic...fessor-shu-ou-shan-speaks-on-nascent-proteins |access-date=2024-05-08 |website=The Johns Hopkins News-Letter |language=en-US}}</ref>
She studies [[Chaperone (protein)|molecular chaperones]] (proteins that assist in the folding or unfolding process) and how they protect proteins from mis-folding, sometimes even repairing mis-folding or aggregation.<ref name=":1" />
== Awards and honours ==
* 2007 [[David and Lucile Packard Foundation]] Fellow<ref>{{Cite web |title=Shan, Shu-ou • The David and Lucile Packard Foundation |url=https://www.packard.org/fellow/shan-shu-ou/ |access-date=2024-05-08 |website=The David and Lucile Packard Foundation |language=en-US}}</ref>
* 2007 [[Arnold and Mabel Beckman]] Fellow<ref>{{Cite web |title=Shu-Ou Shan |url=https://www.beckman-foundation.org/people/shu-ou-shan/ |access-date=2024-05-08 |website=Arnold and Mabel Beckman Foundation |language=en-US}}</ref>
* 2011 [[Protein Society]] Irving Sigal Young Investigator Award<ref>{{Cite web |title=Protein Science Young Investigator Award |url=https://onlinelibrary.wiley.com/page/journal/1469896x/homepage/protein_science_awards.htm}}</ref><ref>{{Cite web |title=Protein Society Awards |url=https://www.proteinsociety.org/protein-society-awards |access-date=2024-05-08 |website=www.proteinsociety.org}}</ref>
* 2013 [[American Chemical Society]] Nobel Laureate Signature Award for Graduate Education in Chemistry<ref>{{Cite web |date=2012-03-16 |title=American Chemical Society Honors Shu-ou Shan |url=https://www.caltech.edu/about/news/american-chemical-society-honors-shu-ou-shan-4239 |access-date=2024-05-08 |website=California Institute of Technology |language=en}}</ref>
* 2013 [[American Society for Biochemistry and Molecular Biology]] Young Investigator Award<ref>{{Cite web |title=Shan honored for work uncovering mechanisms of signal recognition particle |url=https://www.asbmb.org/asbmb-today/people/032513/shan-wins-asbmb-young-investigator-award |access-date=2024-05-08 |website=www.asbmb.org |language=en}}</ref>
* 2020 [[Caltech]] Altair Professor of Chemistry<ref>{{Cite web |date=2020-10-09 |title=Caltech Faculty Receive Named Professorships |url=https://www.caltech.edu/about/news/caltech-faculty-receive-named-professorships-2020 |access-date=2024-05-08 |website=California Institute of Technology |language=en}}</ref>
* 2024 [[National Academy of Sciences]] Award in Molecular Biology<ref>{{Cite web |date=2024-02-08 |title=Caltech’s Shu-ou Shan Recognized for Her Research on Molecular Machines in Protein Folding |url=https://www.wiareport.com/2024/02/national-academy-of-sciences-honors-shu-ou-shan/ |access-date=2024-05-08 |website=Women In Academia Report}}</ref><ref>{{Cite web |date=2024-01-26 |title=Shu-ou Shan Wins National Academy of Sciences Award |url=https://www.caltech.edu/about/news/shan-wins-NAS-award |access-date=2024-05-08 |website=California Institute of Technology |language=en}}</ref>
== Select publications ==
* {{Cite Q|Q38081948}}
* {{Cite Q|Q70998826}}
* {{Cite Q|Q42956366}}
== References ==
Okumaya devam et...