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Inserted publication that details splice variants of STRAD

← Previous revision
Revision as of 20:36, 9 May 2024
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== Function ==== Function ==
Endogenous [[STK11|LKB1]] and STRADα form a complex in which STRADα activates LKB1, resulting in [[phosphorylation]] of both partners. Removal of endogenous LYK5 by [[small interfering RNA]] abrogates LKB1-induced [[G1 phase]] arrest.<ref name="pmid12805220"/> STRADα stabilizes [[STK11|LKB1]] protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with [[STK11|LKB1]]. STRADα is highly spliced in vivo, and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.<ref>{{cite journal | vauthors = Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP | title = STRAD pseudokinases regulate axogenesis and LKB1 stability. | journal = Neural Dev | volume = 9 | issue = 5 | year = 2014 | page = 5 | pmid = 24594058 | doi = 10.1186/1749-8104-9-5 | pmc=4016016 | doi-access = free }}/</ref>Endogenous [[STK11|LKB1]] and STRADα form a complex in which STRADα activates LKB1, resulting in [[phosphorylation]] of both partners. Removal of endogenous LYK5 by [[small interfering RNA]] abrogates LKB1-induced [[G1 phase]] arrest.<ref name="pmid12805220"/> STRADα stabilizes [[STK11|LKB1]] protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with [[STK11|LKB1]]. STRADα is highly spliced in vivo, and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood. <ref>{{cite journal | vauthors = Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP | title = STRAD pseudokinases regulate axogenesis and LKB1 stability. | journal = Neural Dev | volume = 9 | issue = 5 | year = 2014 | page = 5 | pmid = 24594058 | doi = 10.1186/1749-8104-9-5 | pmc=4016016 | doi-access = free }}/</ref>
==Disease linkage====Disease linkage==

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